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THC binds to cannabinoid receptors but generates merely a insignificant response. Synthetic cannabinoids are comprehensive agonists, that means they induce the strongest doable response, and read more in particular reports, they are identified to generally be up to 660 times far more strong than cannabis. They also bind to cannabinoid receptors much more strongly than THC. They have got a 4-five occasions bigger affinity for cannabinoid here receptors than THC.
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